Diflucortolone Valerate Powder

Diflucortolone Valerate Powder

Diflucortolone valerate is a potent synthetic glucocorticoid with anti-inflammatory, anti-allergic, and antipruritic properties. It is primarily used in dermatology for the treatment of inflammatory skin conditions such as eczema, dermatitis, and psoriasis. The valerate ester enhances its penetration and efficacy when applied topically.

General Information:

• Chemical Name: Diflucortolone valerate
• Molecular Formula: C27H36F2O5
• Molecular Weight: 478.57 g/mol
• CAS Number: 59198-59-1
• Appearance: White to off-white crystalline powder

Chemical Structure:

• Category: Corticosteroid
• Subcategory: Topical steroid with potent anti-inflammatory properties.

Key Features of Diflucortolone Valerate Powder

1. Chemical Composition
   • Diflucortolone valerate is a corticosteroid, chemically modified to increase its potency and reduce systemic side effects.
   • Its molecular formula is C27H36F2O5.
2. Mechanism of Action
   • It inhibits the release of inflammatory mediators by reducing prostaglandin and leukotriene production.
   • Modulates immune response by suppressing cytokine release and reducing local inflammation.
3. Uses
   • Commonly formulated in creams or ointments for topical application.
   • Effective in reducing inflammation, redness, and itching associated with chronic and acute skin conditions.
4. Advantages
   • High potency ensures quick and effective relief of symptoms.
   • Minimal systemic absorption when applied in recommended doses, reducing potential side effects.
5. Precautions
   • Prolonged use can lead to thinning of the skin or other corticosteroid-related adverse effects.
   • Should not be used on broken skin, near the eyes, or for extended periods without medical supervision.
6. Storage and Handling
   • Diflucortolone valerate powder should be stored in a cool, dry place, away from light and moisture.
   • Proper personal protective equipment (PPE) should be used when handling the raw material to avoid inhalation or contact with skin and eyes.

Solubility:

• Water: Practically insoluble
• Organic Solvents: Soluble in ethanol, acetone, and chloroform

Purity:

• Minimum Purity: Typically >98% (check specific manufacturer data)

Pharmacological Information:

• Mechanism of Action: Acts as an anti-inflammatory and anti-pruritic by inhibiting prostaglandins and other inflammatory mediators.
• Application: Used topically in dermatological formulations for treating inflammatory skin conditions (e.g., eczema, psoriasis).

Physical Properties:

• Melting Point: Approximately 240–250°C
• Specific Optical Rotation: +90° to +100° (varies based on sample and solvent used)

Safety and Handling:

• Hazards: Avoid inhalation or direct contact with skin or eyes.
• Storage: Store in a cool, dry place away from light, preferably at temperatures below 25°C.
• Shelf Life: Typically 24–36 months when stored properly.

Applications:

• Commonly used in the production of topical creams, ointments, and gels for skin conditions.
• Included as an active pharmaceutical ingredient (API) in medical formulations.

Diflucortolone valerate is a potent corticosteroid commonly used in topical formulations to treat inflammatory skin conditions like eczema and psoriasis. While it is generally safe when used as directed in topical formulations, there are potential risks associated with improper use or exposure to the powdered form. Below are the key warnings and side effects to consider:

Side Effects of Diflucortolone Valerate:

1. Local Side Effects (primarily from topical use):
   • Skin thinning (atrophy)
   • Stretch marks (striae)
   • Skin discoloration
   • Burning, itching, or irritation
   • Acne or acne-like eruptions
   • Folliculitis (inflammation of hair follicles)
2. Systemic Side Effects (from excessive or prolonged use):
   • Hormonal imbalances (HPA axis suppression)
   • Cushing's syndrome symptoms, such as weight gain, high blood pressure, or muscle weakness
   • Delayed wound healing
   • Increased susceptibility to infections
3. Allergic Reactions:
   • Rash, redness, or swelling
   • Severe itching or hives

Warnings for Handling Diflucortolone Valerate Powder:

1. Inhalation Risk:
   • Diflucortolone valerate in powder form can be hazardous if inhaled.
   • It may cause respiratory irritation or systemic absorption, leading to corticosteroid-related side effects.
2. Contact Risk:
   • Direct contact with the skin can result in unintended absorption and localized or systemic effects.
   • Always wear appropriate personal protective equipment (PPE), such as gloves and masks, when handling the powder.
3. Environmental Hazards:
   • Avoid releasing the powder into the environment, as it may pose risks to ecosystems.
4. Storage and Handling:
   • Store in a cool, dry place, away from direct sunlight.
   • Keep the powder away from children and unauthorized personnel.

Precautions for Use:

• Only use products containing diflucortolone valerate as prescribed by a healthcare provider.
• Avoid prolonged or excessive application to large areas of the skin.
• Do not apply to broken or infected skin without medical supervision.
• If symptoms of systemic effects occur, discontinue use and seek medical advice.

Emergency Measures:

• Inhalation: Move to fresh air immediately. Seek medical attention if respiratory symptoms occur.
• Skin Contact: Wash the area thoroughly with soap and water. If irritation persists, consult a healthcare professional.

• Eye Contact: Rinse the eyes with plenty of water for several minutes. If irritation persists, seek medical attention.